POSSIBLE MECHANISMS UNDERLYING THE SPECIAL VULNERABILITY OF DOPAMINERGIC-NEURONS

被引：26
|
作者：
CARLSSON, A
FORNSTEDT, B
机构：
[1] Department of Pharmacology, University of Göteborg, Göteborg
[2] Department of Pharmacology, University of Göteborg, Göteborg, S-400 33
来源：
ACTA NEUROLOGICA SCANDINAVICA | 1991年 / 84卷
关键词：
DOPAMINE METABOLITES; 5-S-CYSTEINYL ADDUCTS OF CATECHOLS; PARKINSONS DISEASE; CEREBROSPINAL FLUID;
D O I：
10.1111/j.1600-0404.1991.tb05014.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Endogenous or exogenous agents may account for the special vulnerability of dopaminergic neutrons. The present paper deals primarily with the possible role of toxic quinoid metabolites of catechols formed by autoxidation. The study of 5-S-cysteinyl adducts of these metabolites may provide clues to underlying mechanisms. In addition these adducts may serve as markers of Parkinson's disease.
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页码：16 / 18
页数：3
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