SYNTHESIS OF SUBSTITUTED 5-HYDROTHIAZOLO[4,3-B]-1,3,4-OXADIAZOLES, 5-HYDROTHIAZOLO[4,3-B]-1,3,4-THIADIAZOLES, AND 5-HYDROTHIAZOLO[3,4-B]-1,2,4-TRIAZOLES AS POTENTIAL ANTIFUNGAL AGENTS

被引：3
|
作者：
SINGH, H
YADAV, LDS
SHUKLA, SN
DWIVEDI, R
机构：
[1] Department of Chemistry, University of Gorakhpur
[2] Department of Chemistry, University of Allahabad
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1992年 / 40卷 / 08期
关键词：
D O I：
10.1021/jf00020a024
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
2-Aryl-3-(3-arylthioureido)-4-thiazolidinones (IIIa-d) were prepared by addition-condensation of aldehyde 4-arylthiosemicarbazones(IIa-d)and mercaptoacetic acid. 5-Aryl-2-(arylamino)-5-hydrothiazolo-[4,3-b]1,3,4-thiadiazoles (IVa-d), the corresponding thiazolo[4,3-b]-1,3,4-oxadiazoles (Va-d), and 1,5-diaryl-5-hydro-2-mercaptothiazolo[3,4-b]-1,2,4-triazoles were obtained by chemoselective intramolecular heterocyclization of IIIa-d with concentrated H2SO4, CH3I, and NaOH, respectively. Compounds IIIa-d-VIa-d were compared with Dithane M-45, a commercial fungicide, for their antifungal action against Aspergillus flavus and Fusarium solani. The screening results have been correlated with the structural features of the tested compounds.
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页码：1409 / 1412
页数：4
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