ATP ACTIVATES JUNCTIONAL AND EXTRAJUNCTIONAL ACETYLCHOLINE-RECEPTOR CHANNELS IN ISOLATED ADULT-RAT MUSCLE-FIBERS

被引：17

作者：

MOZRZYMAS, JW ^{[1
]}

RUZZIER, F ^{[1
]}

机构：

[1] UNIV TRIESTE,INST PHYSIOL,VIA FLEMING 22,I-34127 TRIESTE,ITALY

来源：

NEUROSCIENCE LETTERS | 1992年 / 139卷 / 02期

关键词：

EXTRACELLULAR ATP; ISOLATED ADULT RAT MUSCLE FIBER; SINGLE-CHANNEL RECORDING; ACH-ACTIVATED CHANNEL;

D O I：

10.1016/0304-3940(92)90556-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Single-channel recordings in the cell-attached configuration were made on freshly dissociated and cultured rat muscle fibres. We demonstrate that ATP (50-100-mu-M) elicits single channel currents in freshly isolated fibres. These ATP-activated channels have a slope conductance similar to that determined for ACh-activated channels but exhibit a shorter open time. We also show that ATP activates extrajunctional AChR-channels in the membrane of long-term cultured muscle fibres. Here the ATP activated channel has a slope conductance and open time characteristics similar to those of the ACh-activated channel.

引用

页码：217 / 220

页数：4

共 45 条

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JOURNAL OF MEMBRANE BIOLOGY, 1993, 136 (01): : 31 - 42
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IGUSA, Y
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 405 : 169 - 185
[26] SELECTIVE EXPRESSION OF AN ACETYLCHOLINE RECEPTOR-LACZ TRANSGENE IN SYNAPTIC NUCLEI OF ADULT MUSCLE-FIBERS
SANES, JR
JOHNSON, YR
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DEVELOPMENT, 1991, 113 (04): : 1181 - &
[27] SYNAPSE-SPECIFIC EXPRESSION OF ACETYLCHOLINE-RECEPTOR GENES AND THEIR PRODUCTS AT ORIGINAL SYNAPTIC SITES IN RAT SOLEUS MUSCLE-FIBERS REGENERATING IN THE ABSENCE OF INNERVATION
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DEVELOPMENT, 1992, 116 (01): : 41 - 53
[28] ESTABLISHMENT OF NEUROMUSCULAR CONTACTS IN CULTURES OF RAT EMBRYONIC-CELLS - EFFECT OF TETRODOTOXIN ON MATURATION OF MUSCLE-FIBERS AND ON FORMATION AND MAINTENANCE OF ACETYLCHOLINESTERASE AND ACETYLCHOLINE-RECEPTOR CLUSTERS
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DEVELOPMENTAL NEUROSCIENCE, 1982, 5 (04) : 314 - 325
[29] INVITRO REINNERVATION OF ADULT-RAT MUSCLE-FIBERS BY FOREIGN NEURONS AND TRANSFORMED CHROMAFFIN PC12 CELLS
RUZZIER, F
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PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1988, 234 (1274): : 1 - 9
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TATTERSALL, JEH
JOURNAL OF PHYSIOLOGY-LONDON, 1989, 418 : P187 - P187

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