EFFECT OF TUMOR-NECROSIS-FACTOR ON CELL-PROLIFERATION KINETICS AND SISTER CHROMATID EXCHANGE FREQUENCY IN HUMAN-LYMPHOCYTES

被引：6

作者：

LAZUTKA, JR

RUDAITIENE, S

机构：

[1] Ecological Genetics Laboratory, Vilnius University, 232009 Vilnius

来源：

CARCINOGENESIS | 1991年 / 12卷 / 07期

关键词：

D O I：

10.1093/carcin/12.7.1355

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recombinant human tumor necrosis factor-alpha (TNF) was found to cause a significant increase in cell proliferation rates and sister chromatid exchange (SCE) frequency in phytoemagglutinin-stimulated human lymphocytes in vitro. The cells were treated for the entire cultivation time with 10, 50, 100, 500, 1000 and 5000 U/ml TNF. Cell proliferation rates, as measured by the replication index, increased significantly (P < 0.01) in a concentration-independent manner. The maximal extent of SCE induction (15.18 +/- 0.57 versus 10.26 +/- 0.45 SCEs/cell in control, P < 0.001) was observed with 50 U/ml TNF.

引用

页码：1355 / 1357

页数：3

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