EFFECT OF TUMOR-NECROSIS-FACTOR ON CELL-PROLIFERATION KINETICS AND SISTER CHROMATID EXCHANGE FREQUENCY IN HUMAN-LYMPHOCYTES

被引：6
|
作者：
LAZUTKA, JR
RUDAITIENE, S
机构：
[1] Ecological Genetics Laboratory, Vilnius University, 232009 Vilnius
来源：
CARCINOGENESIS | 1991年 / 12卷 / 07期
关键词：
D O I：
10.1093/carcin/12.7.1355
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recombinant human tumor necrosis factor-alpha (TNF) was found to cause a significant increase in cell proliferation rates and sister chromatid exchange (SCE) frequency in phytoemagglutinin-stimulated human lymphocytes in vitro. The cells were treated for the entire cultivation time with 10, 50, 100, 500, 1000 and 5000 U/ml TNF. Cell proliferation rates, as measured by the replication index, increased significantly (P < 0.01) in a concentration-independent manner. The maximal extent of SCE induction (15.18 +/- 0.57 versus 10.26 +/- 0.45 SCEs/cell in control, P < 0.001) was observed with 50 U/ml TNF.
引用
收藏
页码：1355 / 1357
页数：3
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