METABOLIC PATHWAY FOR 2-KETO-L-GULONIC ACID FORMATION IN GLUCONOBACTER-MELANOGENUS IFO-3293

被引：30
|
作者：
HOSHINO, T
SUGISAWA, T
TAZOE, M
SHINJOH, M
FUJIWARA, A
机构：
[1] Department of Applied Microbiology, Nippon Roche Research Center, Kamakura, Kanagawa, 247, 200, Kajiwara
来源：
AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1990年 / 54卷 / 05期
关键词：
D O I：
10.1080/00021369.1990.10870126
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
The l-sorbosone pathway for 2-keto-l-gulonic acid (2KGA) formation from l-sorbose in Gluconobacter melanogenus IFO 3293 was confirmed. l-Sorbose dehydrogenase, which catalyzes the conversion of l-sorbose to l-sorbosone, was found in the membrane fraction of the microorganism, and l-sorbosone dehydrogenase in the cytosol fraction. The latter enzyme requires NAD or NADP as a cofactor. 2KGA was reduced to l-idonic acid by 2KGA reductase, but l -idonic acid was re-oxidized to 2KGA by membrane-bound l-idonate dehydrogenase. © 1990 by the Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.
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页码：1211 / 1218
页数：8
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