THE 5' REGION OF THE HUMAN THYROGLOBULIN GENE CONTAINS MEMBERS OF THE ALU FAMILY

被引：8
|
作者：
TARGOVNIK, H
PAZ, C
CORACH, D
CHRISTOPHE, D
机构：
[1] UNIV BUENOS AIRES, FAC FARM & BIOQUIM, CATEDRA GENET & BIOL MOLEC, BUENOS AIRES, ARGENTINA
[2] UNIV LIBRE BRUXELLES, INST RECH INTERDISCIPLINAIRE, B-1050 BRUSSELS, BELGIUM
来源：
THYROID | 1992年 / 2卷 / 04期
关键词：
D O I：
10.1089/thy.1992.2.321
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Repeated sequences were identified in the 5' region of the human Tg gene in introns 4, 5, 10, and 11. Another repeated cluster was located in the 5' flanking sequences, approximately 6 Kb upstream from the first exon. The nucleotide sequence analysis indicated that these repeated sequences are members of the Alu family. The homology between the sequences of the intron 4 and the Alu consensus was 86%. The Alu member studied was oriented in the direction of transcription of the Tg.
引用
收藏
页码：321 / 324
页数：4
相关论文
共 50 条
  • [21] RECENTLY AMPLIFIED ALU FAMILY MEMBERS SHARE A COMMON PARENTAL ALU SEQUENCE
    DEININGER, PL
    SLAGEL, VK
    MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (10) : 4566 - 4569
  • [22] STRUCTURAL-ANALYSIS OF THE GENE ENCODING HUMAN GASTRIN - THE LARGE INTRON CONTAINS AN ALU SEQUENCE
    ITO, R
    SATO, K
    HELMER, T
    JAY, G
    AGARWAL, K
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (15): : 4662 - 4666
  • [23] CLONING OF THE MEMBERS OF THE HUMAN CYSTATIN GENE FAMILY
    SAITOH, E
    ISEMURA, S
    SANADA, K
    JOURNAL OF DENTAL RESEARCH, 1990, 69 : 167 - 167
  • [24] STRUCTURE AND VARIABILITY OF RECENTLY INSERTED ALU FAMILY MEMBERS
    BATZER, MA
    KILROY, GE
    RICHARD, PE
    SHAIKH, TH
    DESSELLE, TD
    HOPPENS, CL
    DEININGER, PL
    NUCLEIC ACIDS RESEARCH, 1990, 18 (23) : 6793 - 6798
  • [25] MESSENGER-RNA IN HUMAN-CELLS CONTAINS SEQUENCES COMPLEMENTARY TO THE ALU FAMILY OF REPEATED DNA
    CALABRETTA, B
    ROBBERSON, DL
    MAIZEL, AL
    SAUNDERS, GF
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10): : 6003 - 6007
  • [26] THE HUMAN THYROGLOBULIN GENE IS OVER 300 KB LONG AND CONTAINS INTRONS OF UP TO 64 KB
    BAAS, F
    VANOMMEN, GJB
    BIKKER, H
    ARNBERG, AC
    DEVIJLDER, JJM
    NUCLEIC ACIDS RESEARCH, 1986, 14 (13) : 5171 - 5186
  • [27] Insertion of an Alu Element in Thyroglobulin Gene as a Novel Cause of Congenital Hypothyroidism
    Bruellman, Ryan
    Watanabe, Yui
    Shareef, Reham
    Abdullah, Mohamed A.
    Dumitrescu, Alexandra
    Strauss, Bernard S.
    Refetoff, Samuel
    Weiss, Roy E.
    THYROID, 2020, 30 (05) : 780 - 782
  • [28] MOLECULAR EVOLUTION OF THE HUMAN ADULT ALPHA-GLOBIN GENE REGION - INSERTION AND DELETION OF ALU FAMILY REPEATS AND NON-ALU DNA-SEQUENCES
    HESS, JF
    FOX, M
    SCHMID, CW
    SHEN, CJ
    FEDERATION PROCEEDINGS, 1983, 42 (07) : 1807 - 1807
  • [29] THE INTERACTION OF THYROID NUCLEAR FACTORS WITH REGION-5 OF THE THYROGLOBULIN GENE
    JUVENAL, G
    CHRISTOPHE, D
    VASART, G
    MEDICINA-BUENOS AIRES, 1987, 47 (06) : 621 - 621
  • [30] STRUCTURAL ORGANIZATION OF THE BOVINE THYROGLOBULIN GENE AND OF ITS 5'-FLANKING REGION
    DEMARTYNOFF, G
    POHL, V
    MERCKEN, L
    VANOMMEN, GJ
    VASSART, G
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 164 (03): : 591 - 599
12345