BLOOD-GLUCOSE CONCENTRATIONS AND PROGRESSION OF DIABETIC-RETINOPATHY - THE 7 YEAR RESULTS OF THE OSLO STUDY
被引:133
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作者:
BRINCHMANNHANSEN, O
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机构:AKER UNIV HOSP,OSLO,NORWAY
BRINCHMANNHANSEN, O
DAHLJORGENSEN, K
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h-index: 0
机构:AKER UNIV HOSP,OSLO,NORWAY
DAHLJORGENSEN, K
SANDVIK, L
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h-index: 0
机构:AKER UNIV HOSP,OSLO,NORWAY
SANDVIK, L
HANSSEN, KF
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h-index: 0
机构:AKER UNIV HOSP,OSLO,NORWAY
HANSSEN, KF
机构:
[1] AKER UNIV HOSP,OSLO,NORWAY
[2] MEDSTAT LTD,OSLO,NORWAY
来源:
BRITISH MEDICAL JOURNAL
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1992年
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304卷
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6818期
关键词:
D O I:
10.1136/bmj.304.6818.19
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Objective - To study insulin dependent diabetic patients for change in non-proliferative retinopathy and its relation to glycaemic control and to various clinical background data. Design - Prospective study with follow up for seven years. Setting - Outpatient departments of university hospitals. Main outcome measures - Glycated haemoglobin concentration; degree of retinopathy. Results - Retinopathy worsened by an overall increase in counts of microaneurysms and haemorrhages from 17 (SD 25) to 45 (58) (p = 0.005). Intensified insulin treatment and home blood glucose monitoring improved concentrations of glycated haemoglobin (HbA1) from 11.2% (2.2%) at the start of the study to a mean of 9-5% (1.5%) over the seven years of the study (p < 0.0001). A mean value for HbA1 > 10% was associated with an increased risk of progression of retinopathy and a mean value < 8.7% was associated with a diminished risk. Multiple regression analysis identified four independent variables as indicative of outcome of retinopathy after seven years: HbA1 value at baseline; the change in HbA1 from start to the mean level through the seven years; duration of diabetes; and retinopathy at start. Age, blood pressure, and urinary albumin excretion were not related to the presence or progression of retinopathy. Conclusion - Secondary intervention by long term lowering of glycated haemoglobin has a beneficial impact on non-proliferative retinopathy. A four factor regression model can determine patients at high risk of severe retinopathy.