SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DEMECLOCYCLINE USING SODIUM MOLYBDATE AS ANALYTICAL REAGENT

被引：0
|
作者：
JELIKICSTANKOV, M
STANKOV, D
MALESEV, D
RADOVIC, Z
机构：
[1] CLIN CTR DR DRAGISA MISOVIC, DEPT BIOCHEM, YU-11000 BELGRADE, YUGOSLAVIA
[2] UNIV BELGRADE, FAC PHARM, INST PHYS CHEM, YU-11000 BELGRADE, YUGOSLAVIA
来源：
MIKROCHIMICA ACTA | 1991年 / 1卷 / 1-2期
关键词：
DEMECLOCYCLINE; SODIUM MOLYBDATE; SPECTROPHOTOMETRY; LEDERMYCIN TABLETS;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
By means of spectroscopic methods it has been found that demeclocycline reacts with molybdate ions forming a complex compound [MoO3HDMTC]2-. The relative stability constant of this compound has been determined by applying spectrophotometric methods. Under optimum conditions for complex formation a very senstivie spectrophotometric method for the estimation of demeclocycline in the concentration range 5.0-35.1-mu-g/ml is proposed. The detection limit of the method is 2.5-mu-g/ml of demeclocycline. The relative standard deviation (n = 10) varies between 0.76% and 1.46%. The method proved to be accurate and sensitive for the analysis of the demeclocycline content in tablets.
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页码：65 / 70
页数：6
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