Experimental brain injury in rats with a controlled cortical impact device model

被引：0

作者：

Dvilevicius, Amylcar Edemilson ^{[1
]}

Prandini, Mirto Nelso ^{[1
]}

Dobrowolski, Samuel ^{[1
]}

Barbosa, Ana Claudia ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Lab Neuromicrocirurgia, Escola Paulista Med Unifesp EPM, Sao Paulo, SP, Brazil

来源：

BRAZILIAN NEUROSURGERY-ARQUIVOS BRASILEIROS DE NEUROCIRURGIA | 2008年 / 27卷 / 02期

关键词：

Traumatic brain injury; Experimental animal model;

D O I：

暂无

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective: To develop a controlled cortical impact model (pneumatic) for experimental traumatic brain injury in rats, without brain exposition. Methods: Based in literature, we developed a pneumatic cortical impact model, and tested in thirty rats, with pathological analysis in all animals. Results: The results of pathological analysis of the studied animals, based in the quantification of the neurons injured for field, demonstrated the effectiveness of the model to produce experimental traumatic injury. Conclusion: This model for experimental traumatic brain injury study offers reproducible and clinically relevant pathological conditions through the application of mechanical forces in traumatic brain injury.

引用

页码：42 / 46

页数：5

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