Experimental brain injury in rats with a controlled cortical impact device model

Objective: To develop a controlled cortical impact model (pneumatic) for experimental traumatic brain injury in rats, without brain exposition. Methods: Based in literature, we developed a pneumatic cortical impact model, and tested in thirty rats, with pathological analysis in all animals. Results: The results of pathological analysis of the studied animals, based in the quantification of the neurons injured for field, demonstrated the effectiveness of the model to produce experimental traumatic injury. Conclusion: This model for experimental traumatic brain injury study offers reproducible and clinically relevant pathological conditions through the application of mechanical forces in traumatic brain injury.