CANDIDATE GENES FOR MULTIPLE ENDOCRINE NEOPLASIA TYPE-1

被引：11
|
作者：
LAGERCRANTZ, J
LARSSON, C
GRIMMOND, S
SKOGSEID, B
GOBL, A
FRIEDMAN, E
CARSON, E
PHELAN, C
OBERG, K
NORDENSKJOLD, M
HAYWARD, NK
WEBER, G
机构：
[1] QUEENSLAND INST MED RES, HUMAN GENET LAB, HERSTON, QLD 4006, AUSTRALIA
[2] UNIV UPPSALA HOSP, DEPT INTERNAL MED, S-75185 UPPSALA, SWEDEN
[3] MD ANDERSON CANC CTR, DEPT ENDOCRINOL, HOUSTON, TX USA
[4] MONTREAL GEN HOSP, DEPT MED, DIV MED GENET, MONTREAL, PQ H3G 1A4, CANADA
来源：
JOURNAL OF INTERNAL MEDICINE | 1995年 / 238卷 / 03期
关键词：
CANDIDATE GENES; CHROMOSOME; 11; MEN1; PLCB3;
D O I：
10.1111/j.1365-2796.1995.tb00930.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this study was to isolate and characterize candidates for the multiple endocrine neoplasia type 1 (MEN1) gene. The development of tumours related to MEN1 is associated with somatic deletions involving the MEN1 locus, suggesting inactivation of a tumour-suppressor gene in this region. We have isolated five cDNA candidates located within the 900 kb remaining for the MEN1 gene, determined their sequence, and characterized their expression in normal tissues and several endocrine tumours. One of the candidates, encoding for phospholipase C-beta 3, showed properties consistent with the idea of a tumour-suppressor gene.
引用
收藏
页码：245 / 248
页数：4
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