CONFORMATIONAL-ANALYSIS OF 4,5-DIHYDRO-1-PHENYL-1H-2,4-BENZODIAZEPINES

被引：5
|
作者：
SANNER, MA
JOSEF, K
JOHNSON, RE
DAMBRA, T
KOWALCZYK, P
KULLNIG, RK
MICHAELS, F
机构：
[1] STERLING WINTHROP INC,DEPT BIOPHYS & COMPUTAT CHEM,RENSSELAER,NY 12144
[2] EASTMAN KODAK CO,DIV ANALYT TECHNOL,ROCHESTER,NY 14626
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 23期
关键词：
D O I：
10.1021/jo00075a042
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Detailed conformational analysis of 1-phenyl-1H-4,5-dihydro-2,4-benzodiazepines using X-ray structures, nuclear Overhauser experiments, variable-temperature H-1 NMR, and MacroModel (MULTIC) reveals a rapid equilibrium between axial and equatorial comformations for the free base of 2. The DCl salt of 2 and 1-methyl-1-phenyl analog 3, however, prefer the axial conformation.
引用
收藏
页码：6417 / 6420
页数：4
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