PHASE-II TRIAL FOR THE EVALUATION OF TRIMETREXATE IN PATIENTS WITH INOPERABLE SQUAMOUS CARCINOMA OF THE ESOPHAGUS

被引:5
|
作者
FALKSON, G
RYAN, LM
HALLER, DG
机构
[1] UNIV PRETORIA, DEPT MED ONCOL, POB 667, PRETORIA 0001, SOUTH AFRICA
[2] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA
[3] HOSP UNIV PENN, PHILADELPHIA, PA 19104 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1992年 / 15卷 / 05期
关键词
TRIMETREXATE; CARCINOMA OF THE ESOPHAGUS;
D O I
10.1097/00000421-199210000-00007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
EST 2287 was a Phase II clinical trial conducted by the Eastern Cooperative Oncology Group (ECOG) designed to evaluate trimetrexate in patients with advanced, measurable, inoperable squamous cell carcinoma of the esophagus. The drug was given at a dose of 12 mg/m2 daily for 5 days every 21 days to patients with carcinoma of the esophagus. The purpose of this study was to evaluate treatment efficacy in terms of tumor response and to assess the toxicity. According to a two-stage stopping rule, the study closed after 15 patients had entered. There were no responses to treatment, and median survival from study entry was 4.3 months. There was one treatment-related death caused by infection. One patient experienced life-threatening hematologic toxicity. Overall severe or worse toxicity occurred in more than half of the patients. It is concluded that additional trials of trimetrexate at this dose and schedule in patients with carcinoma of the esophagus are not warranted.
引用
收藏
页码:433 / 435
页数:3
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