LYMPHOCYTE-TRANSFORMATION ABNORMALITIES IN BOVINE IMMUNODEFICIENCY-LIKE VIRUS-INFECTED CALVES

被引：44
|
作者：
MARTIN, SJ [1 ]
ONEILL, TP [1 ]
BILELLO, JA [1 ]
EISEMAN, JL [1 ]
机构：
[1] VET ADM MED CTR,RES SERV,BALTIMORE,MD 21218
来源：
IMMUNOLOGY LETTERS | 1991年 / 27卷 / 02期
关键词：
ACQUIRED IMMUNODEFICIENCY SYNDROME; AIDS; BOVINE IMMUNODEFICIENCY-LIKE VIRUS; LYMPHOCYTE TRANSFORMATION; LYMPHOCYTE STIMULATION;
D O I：
10.1016/0165-2478(91)90132-T
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bovine immunodeficiency-like virus (BIV) is a lentiviral pathogen of cattle which is genetically and antigenically related to the human immunodeficiency virus (HIV-1). To determine the impact of BIV infection on the bovine immune system we studied the lymphocyte transformation responses of male Holstein calves inoculated with BIV strain R-29 to three mitogens: pokeweed mitogen (PWM), concanavalin A (Con A), and phytohemagglutinin (PHA) at two and six months post-infection. By six months post-inoculation the response to all three mitogens was diminished compared to control animals and remained depressed 10 months post-inoculation. These results demonstrate that a functional impairment of lymphocytes can be observed early in the course of BIV infection, and prior to the onset of overt clinical disease.
引用
收藏
页码：81 / 84
页数：4
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