Intraocular Hemorrhage After Intra-Arterial Chemotherapy for Retinoblastoma in Sickle Cell Trait

被引：4

作者：

Abramson, David H. ^{[1
]}

Marr, Brian P. ^{[1
]}

Brodie, Scott E. ^{[2
]}

Dunkel, Ira J. ^{[3
]}

Lin, Amy ^{[4
]}

Folberg, Robert ^{[5
,6
,7
]}

Gobin, Y. Pierre ^{[8
,9
,10
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Ophthalm Oncol Serv, 70 East 66th St, New York, NY 10021 USA

[2] Mt Sinai Sch Med, Dept Ophthalmol, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA

[4] Univ Illinois, Dept Pathol, Chicago, IL USA

[5] Oakland Univ, William Beaumont Sch Med, Dept Biomed Sci, Rochester, MI USA

[6] Oakland Univ, William Beaumont Sch Med, Dept Ophthalmol, Rochester, MI USA

[7] Oakland Univ, William Beaumont Sch Med, Dept Pathol, Rochester, MI USA

[8] Weill Cornell Med Coll, Dept Neurosurg, Intervent Neuroradiol Serv, New York, NY USA

[9] Weill Cornell Med Coll, Dept Neurol, Intervent Neuroradiol Serv, New York, NY USA

[10] Weill Cornell Med Coll, Dept Radiol, Intervent Neuroradiol Serv, New York, NY USA

来源：

OPEN OPHTHALMOLOGY JOURNAL | 2012年 / 6卷

关键词：

Retinoblastoma; sickle cell; intra-arterial chemotherapy; enucleation;

D O I：

10.2174/1874364101206010001

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Massive intraocular hemorrhage developed in a child with advanced unilateral retinoblastoma after intrarterial treatment with Melphalan and Topotecan. The child tested positive for sickle cell trait. Sickle cell trait may predispose such children to slower vascular transit time, hypoxia, sickling and vascular occlusion caused by catheter induced decreased flow. Enucleation confirmed the ultrasound and selective angiogram findings in addition to a completely calcified tumor. Clinicians should be on the lookout for the association of sickle-cell disease/trait and intraocular hemorrhages after intraarterial chemotherapy to fully understand its clinical significance.

引用

页码：1 / 3

页数：3

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