STRUCTURE AND SEQUENCE OF THE GENE ENCODING THE ALPHA-SUBUNIT OF RAT TRANSLATION INITIATION FACTOR-2B

被引：5
|
作者：
FLOWERS, KM [1 ]
MELLOR, H [1 ]
KIMBALL, SR [1 ]
JEFFERSON, LS [1 ]
机构：
[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1264卷 / 02期
关键词：
PROTEIN SYNTHESIS; INITIATION FACTOR; GENE; (RAT);
D O I：
10.1016/0167-4781(95)00160-I
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic initiation factor-2B (eIF-2B) is a heteropentameric guanine nucleotide exchange factor involved in the recycling of eIF-2 during the translation initiation phase of protein synthesis. The activity of eIF-2B is controlled by diverse mechanisms under a wide range of conditions. As part of our studies into the control of the expression of eIF-2B subunit mRNAs, we have isolated and characterized the rat gene encoding the alpha-subunit of eIF-2B. The gene is comprised of 9 exons which are contained within 8.5 kb of genomic DNA. A comparison of the 5'-flanking region of the gene with that of the previously isolated eIF-2B epsilon gene reveals that both possess a potential binding site for the alpha-Pal transcription factor as well as several other regions of homology.
引用
收藏
页码：163 / 167
页数：5
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