IMPAIRMENT OF ENDOTHELIUM-DEPENDENT RELAXATION OF SUPERIOR MESENTERIC-ARTERY IN GENETICALLY DIABETIC WBN KOB RATS

被引：11
|
作者：
MIYATA, N [1 ]
YAMAURA, H [1 ]
TSUCHIDA, K [1 ]
OKUYAMA, S [1 ]
OTOMO, S [1 ]
KAMATA, K [1 ]
KASUYA, Y [1 ]
机构：
[1] HOSHI UNIV,SCH PHARM,DEPT PHARMACOL,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1993年 / 71卷 / 3-4期
关键词：
ACETYLCHOLINE; A23187; SODIUM NITROPRUSSIDE; INDOMETHACIN; GENETICALLY DIABETIC RATS; ENDOTHELIUM-DERIVED RELAXING FACTOR;
D O I：
10.1139/y93-046
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The endothelium-dependent relaxation of superior mesenteric arteries of Wistar and genetically diabetic WBN/Kob rats was compared. Endothelium-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was similar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) enhanced the relaxation responses to ACh in strips from both WBN/Kob and Wistar rats; however, endothelium-dependent relaxation induced by ACh remained attenuated in WBN/Kob rats. These results show that endothelium-dependent relaxation is impaired not only in thoracic aorta but also in superior mesenteric arteries in genetically diabetic rats.
引用
收藏
页码：297 / 300
页数：4
相关论文
共 50 条
  • [31] CHANGES IN RESPONSIVENESS OF THE AORTA TO VASORELAXANT AGENTS IN GENETICALLY DIABETIC RATS - A STUDY IN WBN KOB RATS
    MIYATA, N
    YAMAURA, H
    TSUCHIDA, K
    OTOMO, S
    KAMATA, K
    KASUYA, Y
    LIFE SCIENCES, 1992, 50 (18) : 1363 - 1369
  • [32] Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery
    Ferreira, H. C.
    Serra, C. P.
    Endringer, D. C.
    Lemos, V. S.
    Braga, F. C.
    Cortes, S. F.
    PHYTOMEDICINE, 2007, 14 (7-8) : 473 - 478
  • [33] Maturational changes of endothelium-dependent relaxation in guinea-pig mesenteric artery
    von der Weid, PY
    Roizes, S
    FASEB JOURNAL, 2005, 19 (04): : A725 - A726
  • [34] Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery
    Chen, ZY
    Su, YL
    Lau, CW
    Law, WI
    Huang, Y
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 374 (01) : 41 - 47
  • [35] AGE-DEPENDENT DECREASE IN ENDOTHELIUM-DEPENDENT HYPERPOLARIZATIONS TO ENDOTHELIN-3 IN THE RAT MESENTERIC-ARTERY
    NAKASHIMA, M
    VANHOUTTE, PM
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 22 : S352 - S354
  • [36] PHARMACOLOGICAL NATURES OF CAFFEINE-INDUCED ENDOTHELIUM-DEPENDENT AND ENDOTHELIUM-INDEPENDENT CONTRACTION IN CANINE MESENTERIC-ARTERY
    JINO, H
    KURAHASHI, K
    USUI, H
    SHIRAHASE, H
    NAKATA, Y
    SHIMIZU, Y
    LIFE SCIENCES, 1995, 57 (12) : 1155 - 1162
  • [37] THE ROLE OF SARCOPLASMIC-RETICULUM IN ENDOTHELIUM-DEPENDENT AND ENDOTHELIUM-INDEPENDENT RHYTHMIC CONTRACTIONS IN THE RABBIT MESENTERIC-ARTERY
    OMOTE, M
    MIZUSAWA, H
    ACTA PHYSIOLOGICA SCANDINAVICA, 1993, 149 (01): : 15 - 21
  • [38] CHRONIC ETHANOL CONSUMPTION ENHANCES ENDOTHELIUM-DEPENDENT RELAXATION IN THE RAT SUPERIOR MESENTERIC ARTERIES
    Kudo, R.
    Yuui, K.
    Kasuda, S.
    Hatake, K.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2018, 42 : 18A - 18A
  • [39] Endothelium-dependent and-independent relaxation induced by resveratrol in rat superior mesenteric arteries
    Chen, Yulong
    Xu, Cangbao
    Wei, Yahui
    Zhang, Yaping
    Cao, Ailan
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (04) : 2241 - 2246
  • [40] AGE-RELATED DECREASE IN ENDOTHELIUM-DEPENDENT DILATOR RESPONSE TO HISTAMINE IN RAT MESENTERIC-ARTERY
    MORITOKI, H
    HOSOKI, E
    ISHIDA, Y
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 126 (1-2) : 61 - 67
12345