INCREASE IN GALANIN GENE-EXPRESSION IN LOCUS-CERULEUS NEURONS OF THE RAT FOLLOWING RESERPINE TREATMENT

被引：8
|
作者：
KADOWAKI, K [1 ]
EMSON, PC [1 ]
机构：
[1] AFRC,INST ANIM PHYSIOL & GENET,DEPT PEDIAT,MRC GRP,CAMBRIDGE CB2 4AT,ENGLAND
来源：
MOLECULAR BRAIN RESEARCH | 1992年 / 15卷 / 1-2期
关键词：
GALANIN; LOCUS-CERULEUS; RESERPINE; TYROSINE HYDROXYLASE; NONRADIOACTIVE INSITU HYBRIDIZATION;
D O I：
10.1016/0169-328X(92)90164-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Changes in galanin mRNA content in locus coeruleus neurones of the rat were studied after reserpine treatment (10 mg/kg s.c.) using an in situ hybridization technique and an alkaline phosphatase labelled oligodeoxynucleotide probe. An increase in galanin mRNA content in locus coeruleus neurones was detected as early as 3 h after reserpine treatment when compared to vehicle injected rats. A maximal increase in mRNA content was detected at 3 days after reserpine treatment. This transient increase in galanin mRNA content had subsided by post treatment day 20. The response of locus coeruleus neurones to the single reserpine injection was heterogeneous; cells in the dorsal portion of the nucleus exhibiting a greater response than ventrally located cells.
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页码：156 / 160
页数：5
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