EFFECTS OF 17-HYDROXYWORTMANNIN ON SERINE THREONINE-PROTEIN KINASES IN HUMAN BLOOD-PLATELETS

被引：1

作者：

KOCHER, M ^{[1
]}

CLEMETSON, KJ ^{[1
]}

机构：

[1] UNIV BERN,THEODOR KOCHER INST,FREIESTR 1,CH-3012 BERN,SWITZERLAND

来源：

FEBS LETTERS | 1991年 / 291卷 / 02期

关键词：

PLATELET; PROTEIN KINASE; AGGREGATION; SIGNAL TRANSDUCTION; THROMBIN; FUNGAL METABOLITE;

D O I：

10.1016/0014-5793(91)81321-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinases are involved in signal transduction in human blood platelets. A number of renaturable protein kinases have increased in vitro activities compared to controls due to covalent modifications when intact platelets are activated by thrombin. The effect of the platelet inhibitor 17-hydroxywortmannin (HWT) on these protein kinases was investigated in intact platelets and in vitro. HWT inhibits the increase in activity of these protein kinases but it does not interact directly with their catalytic subunits. We conclude that HWT blocks a step in signal transduction which is necessary to activate these protein kinases via covalent modifications.

引用

页码：363 / 366

页数：4

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