EFFECTS OF METHOTREXATE ON TRANSFECTED DNA STABILITY IN MAMMALIAN-CELLS

被引：71

作者：

PALLAVICINI, MG ^{[1
]}

DETERESA, PS ^{[1
]}

ROSETTE, C ^{[1
]}

GRAY, JW ^{[1
]}

WURM, FM ^{[1
]}

机构：

[1] GENENTECH INC,SAN FRANCISCO,CA 94080

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 01期

关键词：

D O I：

10.1128/MCB.10.1.401

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chromosomal locations, amounts, and level of expression of transfected, amplified c-myc and dihydrofolate reductase sequences were measured in cells cultured in the presence and absence of methotrexate. These studies show that the location and amount of transfected sequences, as well as the level of expression, were more variable when the cells were cultured in methotrexate.

引用

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页码：401 / 404

页数：4

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