EFFECT OF GLUCOCORTICOIDS ON TPA-INDUCED INHIBITION OF GAP-JUNCTIONAL COMMUNICATION AND MORPHOLOGICAL TRANSFORMATION IN SYRIAN-HAMSTER EMBRYO CELLS

被引：6
|
作者：
ROSENG, LE
RIVEDAL, E
机构：
[1] Laboratory for Environmental and Occupational Cancer, Institute for Cancer Research, Norwegian Radium Hospital
来源：
CANCER LETTERS | 1993年 / 72卷 / 1-2期
关键词：
GLUCOCORTICOIDS; CELL COMMUNICATION; CELL TRANSFORMATION;
D O I：
10.1016/0304-3835(93)90006-U
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the effect of TPA on induction of transformed morphology. On the other hand, up to 1000 times higher FA and DEX concentrations did not influence the inhibitory effect of TPA on GJIC. Neither treatment with these glucocorticoids for 4, 24 or 48 h before TPA exposure nor 24 h co-exposure with TPA altered the effect of TPA on GJIC. Thus the potent effect of glucocorticoids as inhibitors of the promotional effect of TPA on morphological transformation in SHE cells does not result in alterations of TPA-induced inhibition of GJIC.
引用
收藏
页码：25 / 30
页数：6
相关论文
共 50 条
  • [31] MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO FIBROBLASTS BY THE ANABOLIC AGENT TRENBOLONE
    SCHIFFMANN, D
    METZLER, M
    NEUDECKER, T
    HENSCHLER, D
    ARCHIVES OF TOXICOLOGY, 1985, 58 (01) : 59 - 63
  • [32] TPA-INDUCED INHIBITION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION IS NOT MEDIATED THROUGH FREE-RADICALS
    HASLER, CM
    FRICK, MA
    BENNINK, MR
    TROSKO, JE
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 103 (03) : 389 - 398
  • [33] Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells
    Zhang, HZ
    Kamendulis, LM
    Jiang, JZ
    Xu, Y
    Klaunig, JE
    CARCINOGENESIS, 2000, 21 (04) : 727 - 733
  • [34] PLOIDY DEPENDENCE OF NEOPLASTIC TRANSFORMATION IN SYRIAN-HAMSTER EMBRYO CELLS
    MORRY, DW
    TSO, POP
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1981, 22 (MAR): : 119 - 119
  • [35] MODIFICATION OF THE RESPONSE OF SYRIAN-HAMSTER EMBRYO CELLS TO TRANSFORMATION BY CARCINOGENS
    RAINERI, R
    POILEY, JA
    PIENTA, RJ
    IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1980, 16 (03): : 207 - 207
  • [36] INHIBITION OF DIFFERENTIATION OF SYRIAN-HAMSTER EPIDERMAL-CELLS IN CULTURE BY TPA
    SISSKIN, EE
    BARRETT, JC
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1979, 20 (MAR): : 197 - 197
  • [37] THE MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS BY CHEMICALS REPORTEDLY NONMUTAGENIC TO SALMONELLA-TYPHIMURIUM
    AMACHER, DE
    ZELLJADT, I
    CARCINOGENESIS, 1983, 4 (03) : 291 - 295
  • [38] INDUCTION OF SELECTIVE DNA AMPLIFICATION AND MORPHOLOGICAL CELL-TRANSFORMATION IN SYRIAN-HAMSTER EMBRYO CELLS
    KLEIN, P
    POOLZOBEL, BL
    YALKINOGLU, O
    SCHLEHOFER, JR
    MUTATION RESEARCH, 1990, 232 (02): : 183 - 190
  • [39] REGULATION OF GAP JUNCTIONAL COMMUNICATION IN SYRIAN-HAMSTER EMBRYO CELLS BY RETINOIC ACID AND 12-O-TETRADECANOYL-PHORBOL-13-ACETATE
    RIVEDAL, E
    SANNER, T
    CARCINOGENESIS, 1992, 13 (02) : 199 - 203
  • [40] ESTROGEN-INDUCED CELL-TRANSFORMATION, MITOTIC INHIBITION AND ANEUPLOIDY IN CULTURED SYRIAN-HAMSTER EMBRYO CELLS
    SUZUKI, N
    TSUTSUI, T
    MAIZUMI, H
    JAPANESE JOURNAL OF PHARMACOLOGY, 1986, 40 : P136 - P136
12345