PHASE-II STUDY OF DAILY ORAL MILTEFOSINE (HEXADECYLPHOSPHOCHOLINE) IN ADVANCED COLORECTAL-CANCER

被引：65
|
作者：
PLANTING, AST
STOTER, G
VERWEIJ, J
机构：
[1] Department of Medical Oncology, Rotterdam Cancer Institute, Dr. Daniel den Hoed Kliniek, 3075 EA Rotterdam
来源：
EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 04期
关键词：
D O I：
10.1016/S0959-8049(05)80142-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
34 patients with metastatic colorectal cancer were treated with the ether lipid miltefosine (hexadecylphosphocholine). Most patients received 3 x 50 mg daily, while in 11 patients the dose could be escalated to 4 x 50 mg daily. Nausea and vomiting were the most frequent side-effects occurring in all but 3 patients, nephrotoxicity was observed in 11 patients. Leucocytosis was observed in 24 and thrombocytosis in 17 patients. 28 patients are evaluable for response. 1 patient obtained a partial response of liver metastases for a duration of 8 months. 3 patients had stable disease while 24 progressed during treatment. We conclude that miltefosine in this dose and schedule has limited activity in colorectal cancer.
引用
收藏
页码：518 / 519
页数：2
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