BIOEQUIVALENCE OF 2 FORMULATIONS OF PIROXICAM

被引：0
|
作者：
MICHOTTE, Y [1 ]
VANKLAVEREN, HP [1 ]
DETAEVERNIER, MR [1 ]
GUSDORF, CF [1 ]
VANHAELST, L [1 ]
机构：
[1] PHARBITA BV,ZAANDAM,NETHERLANDS
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1991年 / 41-1卷 / 03期
关键词：
ANTIINFLAMMATORIES; NONSTEROIDAL; CAS-36322-90-4; PIROXICAM; BIOEQUIVALENCE; CLINICAL PHARMACOKINETICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two separate studies were performed with 12 volunteers in order to demonstrate the bioequivalence of 2 piroxicam (CAS 36322-90-4) tablet and 2 piroxicam suppository formulations after single dose administration. A validated reversed-phase HPLC method with UV-detection is described. Bioequivalence assessment was done by using the posterior probability of a mean ratio between 0.8 and 1.2, and by using the Two One-Sided Tests Procedure (i.e. the 90% confidence interval). The probability approach and the confidence interval approach were compared.
引用
收藏
页码：244 / 246
页数：3
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