A POTENT, ORALLY-ACTIVE, BALANCED AFFINITY ANGIOTENSIN-II AT(1) ANTAGONIST AND AT(2) BINDING INHIBITOR

被引：123

作者：

DELASZLO, SE ^{[1
]}

QUAGLIATO, CS ^{[1
]}

GREENLEE, WJ ^{[1
]}

PATCHETT, AA ^{[1
]}

CHANG, RSL ^{[1
]}

LOTTI, VJ ^{[1
]}

CHEN, TB ^{[1
]}

SCHECK, SA ^{[1
]}

FAUST, KA ^{[1
]}

KIVLIGHN, SS ^{[1
]}

SCHORN, TS ^{[1
]}

ZINGARO, GJ ^{[1
]}

SIEGL, PKS ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT PHARMACOL,W POINT,PA 19486

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 36卷 / 21期

关键词：

D O I：

10.1021/jm00073a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3207 / 3210

页数：4

共 50 条

[41] PHARMACOLOGICAL CHARACTERIZATION OF BOSENTAN, A NEW POTENT ORALLY-ACTIVE NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONIST
CLOZEL, M
BREU, V
GRAY, GA
KALINA, B
LOFFLER, BM
BURRI, K
CASSAL, JM
HIRTH, G
MULLER, M
NEIDHART, W
RAMUZ, H
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1994, 270 (01): : 228 - 235
[42] In vivo pharmacology of an angiotensin AT(1) receptor antagonist with balanced affinity for angiotensin AT(2) receptors
Kivlighn, SD
Zingaro, GJ
Gabel, RA
Broten, TP
Chang, RSL
Ondeyka, DL
Mantlo, NB
Gibson, RE
Greenlee, WJ
Siegl, PKS
EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 294 (2-3) : 439 - 450
[43] SULFONYLUREAS AND SULFONYLCARBAMATES AS NEW NON-TETRAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - DISCOVERY OF A HIGHLY POTENT ORALLY-ACTIVE (IMIDAZOLYLBIPHENYLYL) SULFONYLUREA (HR-720)
DEPREZ, P
GUILLAUME, J
BECKER, R
CORBIER, A
DIDIERLAURENT, S
FORTIN, M
FRECHET, D
HAMON, G
HECKMANN, B
HEITSCH, H
KLEEMANN, HW
VEVERT, JP
VINCENT, JC
WAGNER, A
ZHANG, JD
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (13) : 2357 - 2377
[44] GR127935 - A POTENT ORALLY-ACTIVE 5-HT(1D) RECEPTOR ANTAGONIST
SKINGLE, M
SCOPES, DIC
FENIUK, W
CONNOR, HE
CARTER, MC
CLITHEROW, JW
TYERS, MB
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 : P9 - P9
[45] CI-966 - A POTENT, ORALLY-ACTIVE INHIBITOR OF GABA UPTAKE WITH ANTICONVULSANT ACTIVITY
PAVIA, MR
TAYLOR, CP
LOBBESTAEL, SJ
MAYHUGH, DR
NUGIEL, D
GREGOR, VE
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 199 : 117 - MEDI
[46] POTENT, ORALLY ACTIVE IMIDAZO[4,5-B]PYRIDINE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
MANTLO, NB
CHAKRAVARTY, PK
ONDEYKA, D
CHEN, A
CAMARA, VJ
CHANG, RSL
LOTTI, VJ
SIEGL, PKS
PATCHETT, AA
GREENLEE, WJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 71 - MEDI
[47] MK 287 - A POTENT, SPECIFIC, AND ORALLY-ACTIVE RECEPTOR ANTAGONIST OF PLATELET-ACTIVATING-FACTOR
HWANG, SB
LAM, MH
SZALKOWSKI, DM
MACINTYRE, DE
BACH, TJ
LUELL, S
MEUER, R
SAHOO, SP
ALBERTS, AW
CHABALA, JC
JOURNAL OF LIPID MEDIATORS, 1993, 7 (02): : 115 - 134
[48] METIAMIDE - AN ORALLY-ACTIVE HISTAMINE H-2-RECEPTOR ANTAGONIST
BLACK, JW
DUNCAN, WAM
EMMETT, JC
GANELLIN, CR
HESSELBO, T
PARSONS, ME
WYLLIE, JH
AGENTS AND ACTIONS, 1994, 43 (3-4): : 91 - 96
[49] THE DISCOVERY OF L-749,329, A HIGHLY POTENT, ORALLY-ACTIVE ANTAGONIST OF ENDOTHELIN RECEPTORS
WALSH, TF
FITCH, KJ
CHAKRAVARTY, PK
WILLIAMS, DL
MURPHY, KA
NOLAN, NA
OBRIEN, JA
LIS, EV
PETTIBONE, DJ
KIVLIGHN, SD
GABEL, RA
ZINGARO, GJ
KRAUSE, SM
SIEGL, PKS
CLINESCHMIDT, BV
GREENLEE, WJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 145 - MEDI
[50] ARYL AMIDINES - A NEW CLASS OF POTENT ORALLY-ACTIVE LEUKOTRIENE-B4 ANTAGONIST
MAIN, AJ
BARSKY, LI
MORRISSEY, M
CADILLA, R
BOEHM, C
ZHANG, YC
SUH, HS
BOXER, JB
POWERS, DB
FUJIMOTO, RA
DOTI, RA
HEALY, CT
SELIGMANN, BE
UZIELFUSI, S
JARVIS, MF
SILLS, MA
JACKSON, RH
LIPSON, KE
CHIN, MH
PELLAS, TC
PASTOR, G
FRYER, LR
RAYCHAUDHURI, AA
KOTYUK, BL
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 3 - MEDI

← 1 2 3 4 5 →