COMMON PRINCIPLES IN PROTEIN FOLDING AND ANTIGEN PRESENTATION

被引:2
|
作者
LU, S
REYES, VE
TORGERSON, RR
LEW, RA
HUMPHREYS, RE
机构
关键词
D O I
10.1016/0167-7799(91)90077-U
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The regular recurrence of hydrophobic amino acid residues along a peptide sequence determines the formation of a longitudinal hydrophobic strip when the peptide forms an alpha-helix. An understanding of the ways this may affect both folding of nascent proteins and antigen presentation should facilitate vaccine and therapeutics design.
引用
下载
收藏
页码:238 / 242
页数:5
相关论文
共 50 条
  • [21] ANTIGEN PRESENTATION IN PROTEIN-ENERGY MALNUTRITION
    REDMOND, HP
    GALLAGHER, HJ
    SHOU, J
    DALY, JM
    CELLULAR IMMUNOLOGY, 1995, 163 (01) : 80 - 87
  • [22] Function of proteasomes in protein breakdown and antigen presentation
    Goldberg, A
    FASEB JOURNAL, 2004, 18 (08): : C308 - C308
  • [23] Protein folding principles: Foldons, sequential stabilization, and optional errors
    Mallela, Krishna
    Englander, S. Walter
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [24] PHYS 245-Protein folding and misfolding: Mechanism and principles
    Englander, S. Walter
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [25] Common principles of protein translocation across membranes
    Schatz, G
    Dobberstein, B
    SCIENCE, 1996, 271 (5255) : 1519 - 1526
  • [26] A DATABASE OF PROTEIN-STRUCTURE FAMILIES WITH COMMON FOLDING MOTIFS
    HOLM, L
    OUZOUNIS, C
    SANDER, C
    TUPAREV, G
    VRIEND, G
    PROTEIN SCIENCE, 1992, 1 (12) : 1691 - 1698
  • [27] Common motifs and topological effects in the protein folding transition state
    Hubner, Isaac A.
    Lindberg, Magnus
    Haglund, Ellinor
    Oliveberg, Mikael
    Shakhnovich, Eugene I.
    JOURNAL OF MOLECULAR BIOLOGY, 2006, 359 (04) : 1075 - 1085
  • [28] Superfunneled Energy Landscape of Protein Evolution Unifies the Principles of Protein Evolution, Folding, and Design
    Yan, Zhiqiang
    Wang, Jin
    PHYSICAL REVIEW LETTERS, 2019, 122 (01)
  • [29] Function of the proteasome in protein turnover and antigen presentation.
    Goldberg, AL
    Akopian, T
    Gaczynska, M
    Kisselev, A
    Rock, KL
    Rohrwild, M
    PROTEIN ENGINEERING, 1997, 10 : 10 - 10
  • [30] Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation
    Jaeger, Alex M.
    Stopfer, Lauren
    Lee, Sunmin
    Gaglia, Giorgio
    Sandel, Demi
    Santagata, Sandro
    Lin, Nancy U.
    Trepel, Jane B.
    White, Forest
    Jacks, Tyler
    Lindquist, Susan
    Whitesell, Luke
    CLINICAL CANCER RESEARCH, 2019, 25 (21) : 6392 - 6405