STRUCTURAL AND CONFORMATIONAL STUDY OF SOME N'-P-HALOBENZOYL DERIVATIVES OF THE 3-BETA-AMINO-3-ALPHA-METHOXYCARBONYL(OR CYANO)-N8-SUBSTITUTED NORTROPANES

被引：5

作者：

BURGOS, C

GALVEZ, E

IZQUIERDO, ML

AIRAS, MS

MATESANZ, E

MARTINEZRIPOLL, M

BELLANATO, J

机构：

[1] UNIV ALCALA DE HENARES,DEPT QUIM ORGAN,ALCALA DE HENARES,SPAIN

[2] CSIC,INST CIENCIA MAT,E-28006 MADRID,SPAIN

[3] CSIC,INST ROCASOLANO,EUI CRISTALOG,E-28006 MADRID,SPAIN

[4] CSIC,INST OPT,E-28006 MADRID,SPAIN

来源：

JOURNAL OF MOLECULAR STRUCTURE | 1992年 / 269卷 / 1-2期

关键词：

D O I：

10.1016/0022-2860(92)80010-F

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of N'-p-F(or Cl)-benzoyl derivatives of 3-beta-amino-3-alpha-methoxycarbonyl(or cyano)-N8-substituted nortropanes has been synthesized and studied by IR, H-1 and C-13 NMR spectroscopy, and the crystal structure of 3-alpha-methoxycarbonyl-3-beta-p-chlorobenzamido-tropane (VIb) has been determined by X-ray diffraction. The compounds studied display, in deuterochloroform, a chair envelope conformation very flattened at C3 and puckered at N8, with the benzamido and methoxycarbonyl groups in pseudo-equatorial and pseudo-axial positions respectively. In this solvent, intramolecular hydrogen bondings are observed. As regards the bicyclic system, results are in close agreement with those found for compound Vlb in the crystalline state.

引用

页码：123 / 139

页数：17

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