THE REGULATION OF SODIUM-DEPENDENT TRANSPORT OF ANIONIC AMINO-ACIDS IN CULTURED HUMAN FIBROBLASTS

被引：6

作者：

FRANCHIGAZZOLA, R ^{[1
]}

VISIGALLI, R ^{[1
]}

BUSSOLATI, O ^{[1
]}

GAZZOLA, GC ^{[1
]}

机构：

[1] UNIV PARMA,IST PATOL GEN,I-43100 PARMA,ITALY

来源：

FEBS LETTERS | 1994年 / 352卷 / 02期

关键词：

GROWTH FACTOR; PROLIFERATION; PKC; L-GLUTAMATE; L-ASPARTATE; HUMAN FIBROBLAST;

D O I：

10.1016/0014-5793(94)00929-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In cultured human fibroblasts the transport of anionic amino acids through the sodium-dependent system X(AG)(-) is stimulated rapidly and transiently by phorbol 12,13-dibutyrate. Transport stimulation is consistent with an effect due to the activation of protein kinase C. Bradykinin (1 mu M) and PDGF-AA (100 ng/ml) also stimulate the activity of system X(AG)(-). The bradykinin effect appears to be fully dependent upon PKC activation whereas the stimulation of aspartate transport by PDGF-AA is also due to PKC-independent mechanisms.

引用

页码：109 / 112

页数：4

共 50 条

[21] SODIUM-DEPENDENT TRANSPORT OF NEUTRAL AMINO-ACIDS BY WHOLE CELLS AND MEMBRANE-VESICLES OF STREPTOCOCCUS-BOVIS, A RUMINAL BACTERIUM
RUSSELL, JB
STROBEL, HJ
DRIESSEN, AJM
KONINGS, WN
JOURNAL OF BACTERIOLOGY, 1988, 170 (08) : 3531 - 3536
[22] NEPHRON IN TRANSPORT OF SODIUM, AMINO-ACIDS, AND GLUCOSE
BURG, MB
HOSPITAL PRACTICE, 1978, 13 (10): : 99 - &
[23] SODIUM-DEPENDENT TRANSPORT OF AMINO-ACIDS IN RENAL BRUSH-BORDER MEMBRANE-VESICLES AND URINARY FREE AMINO-ACID EXCRETION IN RATS
TANAKA, H
AKUTSU, T
KOBUTANI, T
NISHI, H
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1989, 53 (06): : 1509 - 1513
[24] ADAPTIVE REGULATION OF AMINO-ACID TRANSPORT IN CULTURED MOUSE AND HUMAN FIBROBLASTS
DALLASTA, V
GAZZOLA, GC
FRANCHIGAZZOLA, R
MANIGA, P
BULLETIN OF MOLECULAR BIOLOGY AND MEDICINE, 1978, 3 (04): : 250 - 259
[25] THE FORMATION OF VESICLES RETAINING SODIUM-DEPENDENT TRANSPORT-SYSTEMS FOR AMINO-ACIDS FROM PROTEIN-DEPLETED MEMBRANES OF PIGEON ERYTHROCYTES
WATTS, C
WHEELER, KP
BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 602 (02) : 460 - 466
[26] RECONSTITUTION OF HUMAN HEPATIC SODIUM-DEPENDENT NEUTRAL AMINO-ACID-TRANSPORT ACTIVITY
MAILLIARD, ME
ZONG, B
KILBERG, MS
CLINICAL RESEARCH, 1990, 38 (02): : A425 - A425
[27] UPTAKE AND METABOLISM OF BRANCHED-CHAIN AMINO-ACIDS IN NORMAL AND MUTANT HUMAN CULTURED FIBROBLASTS
SINGH, S
WILLERS, I
GOEDDE, HW
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1979, 360 (03): : 376 - 376
[28] Characterization of sodium-dependent glucose transport in human kidneys
Cool, B
Dayton, B
Suhar, T
Kan, C
Lin, CW
FASEB JOURNAL, 2002, 16 (04): : A468 - A468
[29] SODIUM-DEPENDENT GLUCOSE-TRANSPORT BY CULTURED PROXIMAL TUBULE CELLS
ALAVI, N
SPANGLER, RA
JUNG, CY
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 899 (01) : 9 - 16
[30] THE MECHANISM AND REGULATION OF SODIUM-DEPENDENT D-GLUCOSE TRANSPORT
TURNER, RJ
FEDERATION PROCEEDINGS, 1985, 44 (03) : R11 - R11

← 1 2 3 4 5 →