THE REGULATION OF SODIUM-DEPENDENT TRANSPORT OF ANIONIC AMINO-ACIDS IN CULTURED HUMAN FIBROBLASTS

被引：6
|
作者：
FRANCHIGAZZOLA, R [1 ]
VISIGALLI, R [1 ]
BUSSOLATI, O [1 ]
GAZZOLA, GC [1 ]
机构：
[1] UNIV PARMA,IST PATOL GEN,I-43100 PARMA,ITALY
来源：
FEBS LETTERS | 1994年 / 352卷 / 02期
关键词：
GROWTH FACTOR; PROLIFERATION; PKC; L-GLUTAMATE; L-ASPARTATE; HUMAN FIBROBLAST;
D O I：
10.1016/0014-5793(94)00929-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In cultured human fibroblasts the transport of anionic amino acids through the sodium-dependent system X(AG)(-) is stimulated rapidly and transiently by phorbol 12,13-dibutyrate. Transport stimulation is consistent with an effect due to the activation of protein kinase C. Bradykinin (1 mu M) and PDGF-AA (100 ng/ml) also stimulate the activity of system X(AG)(-). The bradykinin effect appears to be fully dependent upon PKC activation whereas the stimulation of aspartate transport by PDGF-AA is also due to PKC-independent mechanisms.
引用
收藏
页码：109 / 112
页数：4
相关论文
共 50 条
  • [1] PHORBOL ESTERS STIMULATE THE TRANSPORT OF ANIONIC AMINO-ACIDS IN CULTURED HUMAN FIBROBLASTS
    FRANCHIGAZZOLA, R
    BUSSOLATI, O
    VISIGALLI, R
    ROTOLI, BM
    ROSSI, PA
    GUIDOTTI, GG
    GAZZOLA, GC
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (03) : 1304 - 1310
  • [2] SODIUM-DEPENDENT TRANSPORT OF ANIONIC AMINO-ACIDS MODULATES THE EFFECTS OF L-ASPARAGINASE
    BUSSOLATI, O
    BELLETTI, S
    UGGERI, J
    SALA, R
    GAZZOLA, GC
    FASEB JOURNAL, 1994, 8 (04): : A95 - A95
  • [3] THE RELATIONSHIP BETWEEN SODIUM-DEPENDENT TRANSPORT OF ANIONIC AMINO-ACIDS AND CELL-PROLIFERATION
    BUSSOLATI, O
    UGGERI, J
    ROTOLI, BM
    FRANCHIGAZZOLA, R
    GAZZOLA, GC
    BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1151 (02) : 153 - 160
  • [4] TRANSPORT OF NEUTRAL AMINO-ACIDS IN CULTURED HUMAN-FIBROBLASTS
    GAZZOLA, GC
    DALLASTA, V
    GUIDOTTI, GG
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1980, 255 (03) : 929 - 936
  • [5] SODIUM-DEPENDENT TRANSPORT OF NEUTRAL AND CATIONIC AMINO-ACIDS IN XENOPUS OOCYTES
    HUNDAL, HS
    TAYLOR, PM
    JOURNAL OF PHYSIOLOGY-LONDON, 1990, 420 : P152 - P152
  • [6] TRANSPORT OF CATIONIC AMINO-ACIDS IN HUMAN-FIBROBLASTS
    WHITE, MF
    GAZZOLA, GC
    GUIDOTTI, GG
    FEDERATION PROCEEDINGS, 1980, 39 (06) : 2160 - 2160
  • [7] THE TRANSPORT OF NEUTRAL AMINO-ACIDS IN CULTURED HUMAN KERATINOCYTES
    BUSSOLATI, O
    NUCCI, FA
    ZERMANI, R
    DALLASTA, V
    LONGO, N
    GAZZOLA, GC
    EUROPEAN JOURNAL OF CELL BIOLOGY, 1986, 42 : 14 - 14
  • [8] SODIUM-DEPENDENT TRANSPORT OF BRANCHED-CHAIN AMINO-ACIDS BY A MONENSIN-SENSITIVE RUMINAL PEPTOSTREPTOCOCCUS
    CHEN, GJ
    RUSSELL, JB
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1989, 55 (10) : 2658 - 2663
  • [9] PARTIAL SEPARATION OF A SODIUM-DEPENDENT TRANSPORT-SYSTEM FOR AMINO-ACIDS IN AVIAN ERYTHROCYTE-MEMBRANES
    WATTS, C
    WHEELER, KP
    FEBS LETTERS, 1978, 94 (02) : 241 - 244
  • [10] SODIUM-DEPENDENT AMINO-ACID TRANSPORT IN HUMAN ERYTHROCYTES
    ELLORY, JC
    YOUNG, JD
    JOURNAL OF PHYSIOLOGY-LONDON, 1978, 285 (DEC): : P51 - P52
12345