INTERNAL TRACTS OF TELOMERIC DNA ACT AS SILENCERS IN SACCHAROMYCES-CEREVISIAE

被引:74
|
作者
STAVENHAGEN, JB
ZAKIAN, VA
机构
[1] Fred Hutchinson Cancer Res. Center, Seattle
关键词
TELOMERES; YEAST; POSITION EFFECT; SILENCERS;
D O I
10.1101/gad.8.12.1411
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Telomeric position effect (TPE) refers to the ability of telomeres to repress the transcription of genes in their vicinity. Internal stretches of C(1-3)A DNA, the sequence found at Saccharomyces telomeres, also repressed transcription of nearby genes. This repression, hereafter called C(1-3)A-based silencing, was observed at several chromosomal loci, including on a circular chromosome. The magnitude of C(1-3)A-based silencing was increased by both proximity to a telomere and increased length of the C(1-3)A tracts. C(1-3)A-based silencing was affected by many of the same genes and conditions that influence TPE and acted in an orientation-independent manner. Thus, in yeast, an expanded array of a simple repetitive DNA, C(1-3)A, is sufficient to promote the assembly of a transcriptionally silent chromosomal domain.
引用
收藏
页码:1411 / 1422
页数:12
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