Chromatographic investigations (HPLC, TLC) on brotizolam are described. Quantitative determination of the drug from commercial tablets (Lendormin(R)) was carried out by reversed-phase HPLC method with internal standard technique. Moreover, a stability test of active principle and determination of drug release rates from pharmaceutical formulation in aqueous solutions at different pH values were performed.
机构:
ALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSRALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSR
PASECHNIK, VA
SOLOVYOVA, LY
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ALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSRALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSR
SOLOVYOVA, LY
GORBUNOV, AA
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ALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSRALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSR
GORBUNOV, AA
MITROFANOV, YV
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ALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSRALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSR
MITROFANOV, YV
KARABANOVA, YA
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ALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSRALL UNION HIGHLY PURE BIOL PREPARAT RES INST,7 PUDOZHSKAYA,LENINGRAD 197110,USSR