EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 ON RAT MICROGLIAL CELLS

被引：29
|
作者：
ZIELASEK, J
ARCHELOS, JJ
TOYKA, KV
HARTUNG, HP
机构：
[1] Department of Neurology, Multiple Sclerosis Clinical Research Group, Julius-Maximilians Universität Würzburg
来源：
NEUROSCIENCE LETTERS | 1993年 / 153卷 / 02期
关键词：
MICROGLIAL CELL; LEUKOCYTE ADHESION MOLECULE; GAMMA-INTERFERON; TUMOR NECROSIS FACTOR-ALPHA; MULTIPLE SCLEROSIS; INFLAMMATION;
D O I：
10.1016/0304-3940(93)90306-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglial cells isolated from newborn rat brain displayed a baseline immunoreactivity for intercellular adhesion molecule-1 (ICAM-1) after 10-20 days in culture. ICAM-1 immunoreactivity was enhanced in a time-dependent fashion by exposing the microglial cells to recombinant rat gamma-interferon (gamma-IFN; 100 U/ml) or tumor necrosis factor-alpha (TNF-alpha; 1000 U/ml). We conclude that rat brain macrophages/microgliaI cells can be induced by gamma-IFN and TNF-alpha to express ICAM-1. This may be relevant in the interaction of microglial cells with other brain cells during inflammation of the central nervous system.
引用
收藏
页码：136 / 139
页数：4
相关论文
共 50 条
  • [1] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN VIRAL MYOCARDITIS
    WILLIAMS, JJ
    EISEN, HJ
    TOMASZEWSKI, JE
    ALBELDA, SM
    [J]. CIRCULATION, 1992, 86 (04) : 57 - 57
  • [2] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN VIRAL MYOCARDITIS
    WILLIAMS, JJ
    EISEN, HJ
    TOMASZEWSKI, JE
    ALBELDA, SM
    [J]. CLINICAL RESEARCH, 1992, 40 (03): : A652 - A652
  • [3] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 ON HEMATOPOIETIC PROGENITORS
    ARKIN, S
    NAPRSTEK, B
    GUARINI, L
    FERRONE, S
    LIPTON, JM
    [J]. CLINICAL RESEARCH, 1990, 38 (03): : A775 - A775
  • [4] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN ATHEROSCLEROTIC PLAQUES
    POSTON, RN
    HASKARD, DO
    COUCHER, JR
    GALL, NP
    JOHNSONTIDEY, RR
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 1992, 140 (03): : 665 - 673
  • [5] VASCULAR ADHESION MOLECULE-1 AND INTERCELLULAR-ADHESION MOLECULE-1 EXPRESSION ON RAT-LIVER CELLS AFTER LIPOPOLYSACCHARIDE ADMINISTRATION IN-VIVO
    VANOOSTEN, N
    VANDEBILT, E
    DEVRIES, HE
    VANBERKEL, TJC
    KUIPER, J
    [J]. HEPATOLOGY, 1995, 22 (05) : 1538 - 1546
  • [6] INTERCELLULAR-ADHESION MOLECULE-1 EXPRESSION IN HUMAN KIDNEYS WITH GLOMERULONEPHRITIS
    MULLER, GA
    MARKOVICLIPKOVSKI, J
    MULLER, CA
    [J]. CLINICAL NEPHROLOGY, 1991, 36 (04) : 203 - 208
  • [7] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN HEPATOCELLULAR-CARCINOMA
    TORII, A
    HARADA, A
    NAKAO, A
    NONAMI, T
    ITO, M
    TAKAGI, H
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 1993, 53 (04) : 239 - 242
  • [8] INTERCELLULAR-ADHESION MOLECULE-1 EXPRESSION IN CELIAC-DISEASE
    STURGESS, RP
    MACARTNEY, JC
    NELUFER, JM
    MAKGOBA, MW
    HASKARD, DO
    CICLITIRA, PJ
    [J]. GUT, 1990, 31 (05) : A590 - A590
  • [9] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN HEPATOCELLULAR-CARCINOMA
    TORII, A
    HARADA, A
    NAKAO, A
    NONAMI, T
    NAKAYAMA, A
    ITO, M
    TAKAGI, H
    [J]. HEPATOLOGY, 1992, 16 (04) : A178 - A178
  • [10] EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN ALZHEIMERS-DISEASE
    FROHMAN, EM
    FROHMAN, TC
    VANDENNOORT, S
    [J]. ANNALS OF NEUROLOGY, 1989, 26 (01) : 122 - 122
12345