EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 IN HEPATOCELLULAR-CARCINOMA

被引：18
|
作者：
TORII, A
HARADA, A
NAKAO, A
NONAMI, T
ITO, M
TAKAGI, H
机构：
[1] NAGOYA UNIV,SCH MED,DEPT SURG 2,NAGOYA,AICHI 466,JAPAN
[2] NAGOYA UNIV,SCH MED,DEPT PATHOL 1,NAGOYA,AICHI 466,JAPAN
来源：
JOURNAL OF SURGICAL ONCOLOGY | 1993年 / 53卷 / 04期
关键词：
LIVER CANCER; CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE-1; CD54; IMMUNOHISTOCHEMISTRY;
D O I：
10.1002/jso.2930530410
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of intercellular adhesion molecule-1 (ICAM-1) was investigated in frozen sections obtained from 40 resected liver specimens of patients with hepatocellular carcinoma using immunoperoxidase techniques and immunoelectron microscopy. ICAM-1 was expressed in 80% of the HCC specimens on the membrane of cancer cells. In noncancerous regions characterized by cirrhosis in 28 cases and chronic hepatitis in 12 cases, ICAM-1 was rarely expressed on hepatocytes but was expressed mainly on the endothelium of portal vessels and sinusoidal lining cells. These results suggest that expression of ICAM- 1 in hepatocellular carcinoma may be induced by malignant transformation of hepatocytes. (C) 1993 Wiley-Liss, Inc.
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页码：239 / 242
页数：4
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