SCREENING AND IDENTIFICATION OF SUMATRIPTAN AND ITS MAIN METABOLITE BY MEANS OF THIN-LAYER CHROMATOGRAPHY, ULTRAVIOLET SPECTROSCOPY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：0
|
作者：
ROCHHOLZ, G
AHRENS, B
KONIG, F
SCHUTZ, HW
SCHUTZ, H
SENO, H
机构：
[1] UNIV GIESSEN, INST RECHTSMED, D-35392 GIESSEN, GERMANY
[2] CHRISTIAN ALBRECHTS UNIV KIEL, INST LEGAL MED, KIEL, GERMANY
[3] HAMAMATSU UNIV SCH MED, DEPT LEGAL MED, HAMAMATSU, SHIZUOKA 43131, JAPAN
来源：
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 1995年 / 45-2卷 / 09期
关键词：
ANTIMIGRAINE DRUGS; CAS; 103628-46-2; IMIGRAN(R); SUMATRIPTAN; IDENTIFICATION; METABOLITE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sumatriptan (CAS 103628-46-2, 3-[2-(dimethyl-amino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide), a substance for treatment of acute migraine attacks, and its main metabolite are investigated by thin-layer chromatography (TLC), ultraviolet spectroscopy, and gas chromatography/mass spectrometry (GC/MS). The resulting analytical data (corrected hR(f)-values, UV solvent spectra, remission spectra, GC retention indices, and electron impact (EI) mass spectra) including an extraction procedure and differ ent derivatization methods are presented. Their applicability is described for urine analysis.
引用
收藏
页码：941 / 946
页数：6
相关论文
共 50 条
  • [41] COMBINATION OF GAS-CHROMATOGRAPHY/MASS-SPECTROMETRY FOR SEPARATION AND IDENTIFICATION OF STEROIDS
    CURTIUS, HC
    ZEITSCHRIFT FUR KLINISCHE CHEMIE UND KLINISCHE BIOCHEMIE, 1970, 8 (04): : 435 - +
  • [42] IDENTIFICATION OF HYDROXYHALOBIPHENYLS AS THEIR METHYL ETHERS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    TULP, MTM
    OLIE, K
    HUTZINGER, O
    BIOMEDICAL MASS SPECTROMETRY, 1977, 4 (05): : 310 - 316
  • [43] IDENTIFICATION OF ORGANIC IMPURITIES IN METHACRYLATE BY GAS-CHROMATOGRAPHY AND MASS-SPECTROMETRY
    ZORIN, AD
    KIRSH, SI
    TAINOV, AV
    FOMICHEVA, TN
    BORISOVA, ZK
    UMILIN, VA
    KARABANOV, NT
    AGAFONOV, IL
    JOURNAL OF ANALYTICAL CHEMISTRY OF THE USSR, 1988, 43 (06): : 868 - 871
  • [44] IDENTIFICATION BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY OF 150 COMPOUNDS IN PROPOLIS
    GREENAWAY, W
    MAY, J
    SCAYSBROOK, T
    WHATLEY, FR
    ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1991, 46 (1-2): : 111 - 121
  • [45] SEPARATION AND IDENTIFICATION OF STEREOISOMERIC CYCLOBUTANEDIOLS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    TOROK, B
    SZEGLETES, Z
    MOLNAR, A
    JOURNAL OF CHROMATOGRAPHY A, 1994, 668 (02) : 463 - 467
  • [46] IDENTIFICATION OF DRUGS BY COMBINED GAS-CHROMATOGRAPHY AND COMPUTERIZED MASS-SPECTROMETRY
    EHRENTHAL, W
    PFLEGER, K
    HUFNAGEL, D
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1976, 293 : R56 - R56
  • [47] IDENTIFICATION OF IMPURITY COMPONENTS IN TETRAMETHYLTIN BY GAS-CHROMATOGRAPHY AND MASS-SPECTROMETRY
    NOVOTOROV, YN
    NOVOTOROVA, LG
    KOSYAK, AM
    ZORIN, AD
    AGAFONOV, IL
    FESHCHENKO, AG
    CHAROV, AI
    FESHCHENKO, IA
    KLIMOV, KN
    JOURNAL OF ANALYTICAL CHEMISTRY OF THE USSR, 1986, 41 (02): : 276 - 278
  • [48] SIMULTANEOUS ANALYSIS OF 25 PESTICIDES IN CROPS USING GAS-CHROMATOGRAPHY AND THEIR IDENTIFICATION BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    HONG, JK
    EO, YW
    RHEE, JS
    KIM, TJ
    KIM, KJ
    JOURNAL OF CHROMATOGRAPHY, 1993, 639 (02): : 261 - 271
  • [49] USE OF NEW SILYLATING AGENTS FOR IDENTIFICATION OF HYDROXYLATED STEROIDS BY GAS-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    MIYAZAKI, H
    ISHIBASHI, M
    ITOH, M
    NAMBARA, T
    BIOMEDICAL MASS SPECTROMETRY, 1977, 4 (01): : 23 - 35
  • [50] SEPARATION AND IDENTIFICATION OF NATURALLY-OCCURRING ANTHRAQUINONES BY CAPILLARY GAS-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
    VANEIJK, GW
    ROEIJMANS, HJ
    JOURNAL OF CHROMATOGRAPHY, 1984, 295 (02): : 497 - 502
12345