SCREENING AND IDENTIFICATION OF SUMATRIPTAN AND ITS MAIN METABOLITE BY MEANS OF THIN-LAYER CHROMATOGRAPHY, ULTRAVIOLET SPECTROSCOPY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：0
|
作者：
ROCHHOLZ, G
AHRENS, B
KONIG, F
SCHUTZ, HW
SCHUTZ, H
SENO, H
机构：
[1] UNIV GIESSEN, INST RECHTSMED, D-35392 GIESSEN, GERMANY
[2] CHRISTIAN ALBRECHTS UNIV KIEL, INST LEGAL MED, KIEL, GERMANY
[3] HAMAMATSU UNIV SCH MED, DEPT LEGAL MED, HAMAMATSU, SHIZUOKA 43131, JAPAN
来源：
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 1995年 / 45-2卷 / 09期
关键词：
ANTIMIGRAINE DRUGS; CAS; 103628-46-2; IMIGRAN(R); SUMATRIPTAN; IDENTIFICATION; METABOLITE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sumatriptan (CAS 103628-46-2, 3-[2-(dimethyl-amino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide), a substance for treatment of acute migraine attacks, and its main metabolite are investigated by thin-layer chromatography (TLC), ultraviolet spectroscopy, and gas chromatography/mass spectrometry (GC/MS). The resulting analytical data (corrected hR(f)-values, UV solvent spectra, remission spectra, GC retention indices, and electron impact (EI) mass spectra) including an extraction procedure and differ ent derivatization methods are presented. Their applicability is described for urine analysis.
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页码：941 / 946
页数：6
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