PREPARATION OF [I-131] LIPIODOL AS A HEPATOMA THERAPEUTIC AGENT

被引：0
|
作者：
LO, JG
WANG, AY
WEI, YY
LUI, WY
CHI, CW
CHAN, WK
机构：
[1] TAIPEI VET GEN HOSP,TAIPEI,TAIWAN
[2] ACAD SINICA,INST BIOMED SCI,TAIPEI 115,TAIWAN
来源：
APPLIED RADIATION AND ISOTOPES | 1992年 / 43卷 / 12期
关键词：
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An isotopic exchange method was used to label lipiodol with I-131. The labelling efficiency was > 92.5%, and the radiochemical purity of [I-131]lipiodol was above 98% as determined by ITLC. The influencing factors e.g. the beating temperature, reaction time, pH and storage conditions were studied and the optimum conditions were determined. In a pilot study injecting [I-131]lipiodol for the treatment of hepatoma, about 70% of hepatoma patients had a response to the treatment with a reduction of alpha-fetoprotein and decrease of hepatoma sizes. The overall median survival was 9 months (range 2-17 months).
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页码：1431 / 1435
页数：5
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