PHOTOREACTIVATION OF ULTRAVIOLET RADIATION-INDUCED RELEASE OF ARACHIDONIC-ACID FROM MARSUPIAL CELLS

被引：6
|
作者：
KALETA, EW [1 ]
APPLEGATE, LA [1 ]
LEY, RD [1 ]
机构：
[1] LOVELACE FDN MED EDUC & RES,CTR PHOTOMED,2425 RIDGECREST DR SE,ALBUQUERQUE,NM 87108
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1991年 / 54卷 / 05期
关键词：
D O I：
10.1111/j.1751-1097.1991.tb02085.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exposure of an established marsupial cell line, PtK2 (Potorous tridactylus), to ultraviolet radiation (UVR) from an FS-40 sunlamp (280-400 nm) resulted in a fluence-dependent release of radiolabeled arachidonic acid (AA) from cell membranes. Post-UVR, but not pre-UVR, exposure to photoreactivating light reversed UVR-induced pyrimidine dimers in DNA and suppressed the UVR-induced release of AA. These data indicate that DNA damage contributes to the release of AA from membrane phospholipids.
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页码：747 / 752
页数：6
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