LOCALIZATION OF GAMMA-DELTA-T-CELLS TO THE INTESTINAL EPITHELIUM IS INDEPENDENT OF NORMAL MICROBIAL COLONIZATION

被引：261
|
作者：
BANDEIRA, A
MOTASANTOS, T
ITOHARA, S
DEGERMANN, S
HEUSSER, C
TONEGAWA, S
COUTINHO, A
机构：
[1] CIBA GEIGY AG,RES DEPT,CH-4002 BASEL,SWITZERLAND
[2] MIT,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02139
[3] MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 01期
关键词：
D O I：
10.1084/jem.172.1.239
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) α/β i-IEL, but little effect in the pool size or characteristics of γ/δ i-MEL. In young athymic mice, virtually no α/β i-IEL are detected, while considerable numbers of γ/δ i-MEL remain, though reduced in GF animals. © 1990, Rockefeller University Press., All rights reserved.
引用
收藏
页码：239 / 244
页数：6
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