HIGH-DOSE CHEMOTHERAPY WITH ABMT IN SOFT-TISSUE SARCOMAS - A REPORT OF 22 CASES

被引：0

作者：

DUMONTET, C ^{[1
]}

BIRON, P ^{[1
]}

BOUFFET, E ^{[1
]}

BLAY, JY ^{[1
]}

MECKENSTOCK, R ^{[1
]}

CHAUVIN, F ^{[1
]}

PHILIP, I ^{[1
]}

CLAVEL, M ^{[1
]}

BRUNATMENTIGNY, M ^{[1
]}

PHILIP, T ^{[1
]}

机构：

[1] CTR LEON BERARD,28 RUE LAENNEC,F-60373 LYON,FRANCE

来源：

BONE MARROW TRANSPLANTATION | 1992年 / 10卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Twenty-two patients with locally advanced or metastatic soft tissue sarcomas received high dose chemotherapy with autologous bone marrow graft. Eleven patients receiving melphalan also received fractionated total body irradiation. Six patients (four in CR and two in PR) were intensified after first line therapy. Thirteen patients were grafted after chemosensitive relapse: seven in second CR, one in third CR, one in first PR, three in second PR and one in fourth PR. Three patients with primary refractory disease were intensified. The overall response rate in 66% in nine evaluable patients. The overall median survival and disease-free survival were 19 and 15 months, respectively. The actuarial survival rates at 2 and 5 years were 40% and 32% respectively. There was one treatment-related death due to infection. We conclude that high dose chemotherapy is feasible and provides reasonable response rates in patients with advanced soft tissue sarcomas.

引用

页码：405 / 408

页数：4

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