ANALYSIS OF HLA-DR MATCHING IN DNA-TYPED CADAVER KIDNEY-TRANSPLANTS

被引：0
|
作者：
OPELZ, G
MYTILINEOS, J
SCHERER, S
DUNCKLEY, H
TREJAUT, J
CHAPMAN, J
FISCHER, G
FAE, I
MIDDLETON, D
SAVAGE, D
BIGNON, JD
BENSA, JC
NOREEN, H
ALBERT, E
ALBRECHT, G
SCHWARZ, V
机构：
[1] UNIV SYDNEY,TRANSPLANT LAB,SYDNEY,NSW 2006,AUSTRALIA
[2] UNIV VIENNA,TRANSPLANT LAB,A-1010 VIENNA,AUSTRIA
[3] UNIV BELFAST,TRANSPLANT LAB,BELFAST,NORTH IRELAND
[4] UNIV NANTES,TRANSPLANT LAB,F-44035 NANTES,FRANCE
[5] UNIV GRENOBLE 1,TRANSPLANT LAB,F-38041 GRENOBLE,FRANCE
[6] UNIV MINNESOTA,TRANSPLANT LAB,MINNEAPOLIS,MN 55455
[7] UNIV MUNICH,TRANSPLANT LAB,W-8000 MUNICH 2,GERMANY
来源：
TRANSPLANTATION | 1993年 / 55卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of matching for HLA-DR antigens was analyzed retrospectively in 3455 cadaver kidney transplants that were typed by the DNA-RFLP method. HLA-DR matching improved the one-year graft survival rate significantly (P<0.01). Importantly, in 718 first transplants in which the number of mismatches assigned by serological typing was different from that assigned by DNA typing, only the DNA results showed a significant impact of matching on graft outcome (P=0.03). These results demonstrate that DNA typing is clinically relevant. We were unable to confirm that the HLA-DR6 specificity or the DR6-split DRB1 * 1302 are associated with poor graft survival.
引用
收藏
页码：782 / 785
页数：4
相关论文
共 50 条
  • [41] THE INCIDENCE OF THROMBOEMBOLIC DISEASE IN RECIPIENTS OF CADAVER KIDNEY-TRANSPLANTS
    RAO, KV
    ANDERSEN, RC
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1985, 6 (06) : A16 - A16
  • [42] PREDICTION OF THE FATE OF KIDNEY RETRANSPLANTATION - IMPORTANCE OF HLA-DR MATCHING
    BUSSON, M
    BOUTEILLER, AM
    FAUCHET, R
    BETUEL, H
    GEBUHRER, L
    CALOT, M
    PERRIER, P
    PIERRESCHI, J
    MONTEIRO, C
    GUIGNIER, F
    RAFFOUX, C
    HORS, J
    [J]. TRANSPLANTATION PROCEEDINGS, 1985, 17 (06) : 2232 - 2235
  • [43] The Effect of HLA-DR Matching on Pediatric Kidney Transplantation reply
    Stock, Peter G.
    [J]. ARCHIVES OF SURGERY, 2012, 147 (01) : 97 - 98
  • [44] IMPROVED KIDNEY GRAFT-SURVIVAL WITH HLA-DR MATCHING
    FALK, J
    CARDELLA, C
    HALLORAN, P
    ROBINETTE, M
    BEAR, R
    ARBUS, G
    [J]. HUMAN IMMUNOLOGY, 1983, 8 (04) : 308 - 309
  • [45] EFFECT OF BLOOD-GROUP ON RELATION BETWEEN HLA MATCH AND OUTCOME OF CADAVER KIDNEY-TRANSPLANTS
    OPELZ, G
    TERASAKI, PI
    [J]. LANCET, 1977, 1 (8005): : 220 - 222
  • [46] IMPACT OF HLA-DR MATCHING ASSESSED BY DNA ANALYSIS IN KIDNEY-TRANSPLANTATION - A ONE-CENTER STUDY
    NATAF, S
    HOURMANT, MH
    HERRY, P
    CESBRON, A
    BONNEVILLE, F
    CHENEAU, ML
    MULLER, JY
    SOULILLOU, JP
    BIGNON, JD
    [J]. REVUE FRANCAISE DE TRANSFUSION ET D HEMOBIOLOGIE, 1993, 36 (02): : 179 - 189
  • [47] HLA-MATCHING REQUIREMENTS DIFFER BETWEEN MALE AND FEMALE RECIPIENTS OF 1ST CADAVER KIDNEY-TRANSPLANTS TREATED WITH CYCLOSPORINE
    CECKA, JM
    TERASAKI, PI
    [J]. HUMAN IMMUNOLOGY, 1986, 17 (02) : 122 - 123
  • [48] REJECTION OF HLA IDENTICAL RELATED KIDNEY-TRANSPLANTS
    SALAMAN, JR
    GODFREY, AM
    RUSSELL, RB
    BROWN, P
    FESTENSTEIN, H
    [J]. TISSUE ANTIGENS, 1976, 8 (04): : 233 - 238
  • [49] EFFECT OF BLOOD TRANSFUSIONS ON CADAVER KIDNEY-TRANSPLANTS - ANALYSIS OF PATIENTS TRANSPLANTED IN UPPSALA
    SAFWENBERG, J
    BACKMANBAVE, U
    HOGMAN, CF
    [J]. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 1977, : 59 - 61
  • [50] DNA HETERODUPLEX ANALYSIS OF HLA-DRB ALLELES IN SEROLOGICALLY MATCHED CADAVERIC KIDNEY-TRANSPLANTS
    CONNOLLY, JK
    IVINSON, AJ
    SINNOTT, PJ
    MARTIN, S
    PARROTT, NR
    JOHNSON, RWG
    DYER, PA
    [J]. HUMAN IMMUNOLOGY, 1993, 37 : 80 - 80
12345