ANALYSIS OF HLA-DR MATCHING IN DNA-TYPED CADAVER KIDNEY-TRANSPLANTS

被引：0
|
作者：
OPELZ, G
MYTILINEOS, J
SCHERER, S
DUNCKLEY, H
TREJAUT, J
CHAPMAN, J
FISCHER, G
FAE, I
MIDDLETON, D
SAVAGE, D
BIGNON, JD
BENSA, JC
NOREEN, H
ALBERT, E
ALBRECHT, G
SCHWARZ, V
机构：
[1] UNIV SYDNEY,TRANSPLANT LAB,SYDNEY,NSW 2006,AUSTRALIA
[2] UNIV VIENNA,TRANSPLANT LAB,A-1010 VIENNA,AUSTRIA
[3] UNIV BELFAST,TRANSPLANT LAB,BELFAST,NORTH IRELAND
[4] UNIV NANTES,TRANSPLANT LAB,F-44035 NANTES,FRANCE
[5] UNIV GRENOBLE 1,TRANSPLANT LAB,F-38041 GRENOBLE,FRANCE
[6] UNIV MINNESOTA,TRANSPLANT LAB,MINNEAPOLIS,MN 55455
[7] UNIV MUNICH,TRANSPLANT LAB,W-8000 MUNICH 2,GERMANY
来源：
TRANSPLANTATION | 1993年 / 55卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of matching for HLA-DR antigens was analyzed retrospectively in 3455 cadaver kidney transplants that were typed by the DNA-RFLP method. HLA-DR matching improved the one-year graft survival rate significantly (P<0.01). Importantly, in 718 first transplants in which the number of mismatches assigned by serological typing was different from that assigned by DNA typing, only the DNA results showed a significant impact of matching on graft outcome (P=0.03). These results demonstrate that DNA typing is clinically relevant. We were unable to confirm that the HLA-DR6 specificity or the DR6-split DRB1 * 1302 are associated with poor graft survival.
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页码：782 / 785
页数：4
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