CARDIAC TRANSPLANTATION - KETOCONAZOLE REDUCES REQUIREMENTS OF CYCLOSPORINE-A

被引：0

作者：

BECERRA, E ^{[1
]}

ARANGUIZ, E ^{[1
]}

PEDEMONTE, O ^{[1
]}

DEPRADA, MT ^{[1
]}

MERELLO, L ^{[1
]}

ORFALI, C ^{[1
]}

ANINAT, M ^{[1
]}

TORRES, H ^{[1
]}

GONZALEZ, R ^{[1
]}

CHADID, P ^{[1
]}

DELAPRIDA, M ^{[1
]}

BORJA, H ^{[1
]}

ALVAREZ, R ^{[1
]}

TORREGROSA, X ^{[1
]}

KAPLAN, J ^{[1
]}

机构：

[1] HOSP GUSTAVO FRICKE, SERV ANAT PATOL & MED INTERNA, VANA DEL MAR, CHILE

来源：

REVISTA MEDICA DE CHILE | 1991年 / 119卷 / 09期

关键词：

HEART; TRANSPLANTATION; CYCLOSPORINS; KETOCONAZOLE; PROGNOSIS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Use of cyclosporin A has improved survival in patients submitted to cardiac transplantation. However, high cost of cyclosporin poses a problem for many patients in Chile. Ketoconazole is able to reduce hepatic metabolism of cyclosporin and thus prolong therapeutic levels. A 74 to 82% reduction in cyclosporin requirements was obtained in a cardiac transplant patient by adding ketoconazole. No renal damage was detected. Therefore, this drug association may help extend cardiac transplantation programs in Chile.

引用

页码：1038 / 1042

页数：5

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