EFFECTS OF SHORT-CHAIN FATTY-ACID, SODIUM-BUTYRATE, ON OSTEOBLASTIC CELLS AND OSTEOCLASTIC CELLS

被引：60
|
作者：
IWAMI, K
MORIYAMA, T
机构：
[1] Department of Public Health, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 11期
关键词：
D O I：
10.1016/0020-711X(93)90522-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC) formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone marrow cells.
引用
收藏
页码：1631 / 1635
页数：5
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