Correlation between the Concentration of the Matrixmetalloproteinase-1 Tissue Levels and Clinical Parameters in Periodontitis-affected Patients

To determine the correlation between the concentration of the collagenase MMP-1 in the inflammatory gingival bounding tissue in patients with a chronic form of periodontal disease with the clinical parameters. 32 patients with a chronic form of periodontal disease were followed, according to the criteria set by AAP 1999. The index of dental plaque Silness-Loe was clinically followed, the index of gingival inflammation Loe-Silness, the index of clinical attachment loss and the Miller-Pelzer index of bone resorption. For setting the concentrations of MMP-1, the quantitative enzyme method was used, with the commercial set Colorimetic SensoLyte MMP-1 ELISA Kit. We found the presence of a positive correlation between IDP and the examined MMP-1 (r = 0.55). Importantly, a positive correlation was present between IGI and MMP-1 (r = 0.77). The loss of attachment and resorption of the alveolar bone were strongly correlated with the concentrations of MMP-1 (r=0.83 and r=0.76). The microorganisms from the biofilm initiate the production of the collagenase MMPs-1 and their concentrations rise with the development of the inflammatory processes, leading to the loss of attachment and resorption of the alveolar bone.