DETERMINATION OF DIHYDROQINGHAOSU IN BLOOD BY PYROLYSIS-GAS CHROMATOGRAPHY-MASS SPECTROMETRY

被引：24
|
作者：
THEOHARIDES, AD
SMYTH, MH
ASHMORE, RW
HALVERSON, JM
ZHOU, ZM
RIDDER, WE
LIN, AJ
机构：
[1] Department of Pharmacology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, United States
来源：
ANALYTICAL CHEMISTRY | 1988年 / 60卷 / 02期
关键词：
BIOLOGICAL MATERIALS - Chromatographic Analysis - ETHERS - ORGANIC COMPOUNDS - Spectroscopic Analysis - SPECTROSCOPY - Applications;
D O I：
10.1021/ac00153a004
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive and specific method using packed or capillary column gas chromatography/mass spectrometry (GC/MS) has been developed for the quantitation of the major active metabolite dihydroqinghaosu (DQHS) of the antimalarial drug artesunic acid in blood. Quantification is achieved with an internal standard method, petroleum ether or n-butyl chloride extraction of blood and gas chromatography/mass spectrometry analysis of the extract with selected ion monitoring. The method is currently being used for pharmacokinetic and metabolism studies in animals.
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页码：115 / 120
页数：6
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