ASYMMETRIC MICHAEL ADDITION OF THIOLS TO (1R,2R,4R)-(-)2,10-N-ENOYLCAMPHORSULTAM

被引：19
|
作者：
TSAI, WJ
LIN, YT
UANG, BJ
机构：
[1] NATL TSING HUA UNIV,DEPT CHEM,HSINCHU 30043,TAIWAN
[2] CHINA STEEL CORP,DEPT NEW MAT RES & DEV,KAOHSIUNG 81233,TAIWAN
来源：
TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 07期
关键词：
D O I：
10.1016/0957-4166(94)80155-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Lithium base promoted stereoselective Michael addition of thiols to N-methacryloylcamphorsultam produced the corresponding addition products in 66% to 90% diastereoselectivity. Hydrolysis of the Michael product with three equivalents of lithium hydroxide in THF/H2O gave the corresponding optically active beta-thioester with no sign of any racemization, and recovered camphorsultam quantitatively.
引用
收藏
页码：1195 / 1198
页数：4
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