In search of the Holy Grail

This review is a compilation of the history of medicine in heart failure that we will present in four chapters during the current year. They will describe the efforts of medicine and related sciences to combat this serious problem which is the end point of almost all cardiovascular pathologies. Our objective is to try to correlate in this document the history of different pathophysiological and therapeutic models of heart failure and its evolution to the present in an inseparable way to the history of medicine and, particularly, to the history of cardiology.