CALCIUM-CHANNEL BLOCKING-AGENTS AND POTASSIUM-STIMULATED RELEASE OF GLUTAMATE FROM CEREBELLAR SLICES

被引：27
|
作者：
DICKIE, BGM [1 ]
DAVIES, JA [1 ]
机构：
[1] UNIV WALES COLL MED,DEPT PHARMACOL & THERAPEUT,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 229卷 / 01期
关键词：
CA2+ CHANNEL BLOCKERS; GLUTAMATE; CEREBELLAR SLICES;
D O I：
10.1016/0014-2999(92)90291-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of calcium channel blockers and tetrodotoxin on the potassium-stimulated release of endogenous glutamate from rat cerebellar slices was assessed. Verapamil (10 muM), omega-conotoxin (1 and 10 muM) and cobalt (2 mM) all significantly decreased release. Amiloride (100 muM) and tetrodotoxin (0.5 and 1 muM) had no effect. The results suggest a role for N-type voltage-operated calcium channels in the potassium-stimulated release of glutamate.
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页码：97 / 99
页数：3
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