A HIGH PHOSPHOTYROSINE PHOSPHATASE-ACTIVITY IS PRESENT IN DIFFERENTIATING BOVINE LENS CELLS

被引：7
|
作者：
BLANQUET, PR
CROQUET, F
机构：
[1] Unité de Recherches Gérontologiques, INSERM U118, affiliée CNRS, 75016 Paris
来源：
CELL BIOLOGY INTERNATIONAL | 1995年 / 19卷 / 02期
关键词：
D O I：
10.1006/cbir.1995.1052
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Activity of phosphotyrosine - protein phosphatases (PTPases) has been investigated in the different cellular regions of bovine eye lens. PTPases were tested in cellular detergent extracts using phospholabelled synthetic peptides and p-nitrophenyl phosphate. We show that a high PTPase activity is only present in cells which undergo differentiation, namely the equatorial epithelium and cortex fiber cells. Since this activity is found to be severely inhibited by a specific inhibitor of receptor-type PTPases, it can be suggested that one or more members of this class of PTPases might play an important role in the lens differentiation process.
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页码：121 / 128
页数：8
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