EFFECT OF L-CARNITINE ON THE CELLULAR-DISTRIBUTION OF CARNITINE AND ITS ACYL DERIVATIVES IN THE ISCHEMIC HEART

被引：0
|
作者：
FUJISAWA, S [1 ]
KOBAYASHI, A [1 ]
HIRONAKA, Y [1 ]
YAMAZAKI, N [1 ]
机构：
[1] HAMAMATSU UNIV SCH MED, DEPT INTERNAL MED 3, HAMAMATSU, SHIZUOKA 43131, JAPAN
来源：
JAPANESE HEART JOURNAL | 1992年 / 33卷 / 05期
关键词：
CELLULAR DISTRIBUTION OF CARNITINE; ISCHEMIC MYOCARDIUM; CYTOSOLIC COMPARTMENT; MITOCHONDRIAL COMPARTMENT; LONG-CHAIN ACYLCARNITINE; L-CARNITINE TREATMENT;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The purpose of this study was to investigate the cellular distribution of carnitine and its acyl derivatives in the normal and ischemic myocardium, and the effects of exogenous 1-carnitine on this distribution and mitochondrial function in the ischemic dog heart. Under nonischemic conditions, about 93% of the total cellular carnitine was located in the cytosolic compartment and 6.5% in the mitochondrial compartment. Sixty minutes of ischemia induced a decrease in the cytosolic free carnitine content, but caused the accumulation of long-chain acylcarnitine in the cytosolic and mitochondrial compartments. Treatment with 1-carnitine (30 or 100 mg/kg, i.v.) inhibited the mitochondrial accumulation of long-chain acylcarnitine. Free fatty acid (FFA) metabolism in the mitochondria differs from that in the cytosol. So, it is necessary to investigate the changes in FFA metabolism in both of these cellular compartments. Our results suggest that 1-carnitine has a protective effect on the ischemic heart by selectively reducing mitochondrial accumulation of long-chain acylcarnitine.
引用
收藏
页码：693 / 705
页数：13
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